![]() ![]() ![]() Ģ.1 Role of trauma and genetic predisposition Complicating matters has been the lack of appropriate animal models in which to study keloid development and potential treatment modalities. Certain regulators of the fibrotic cascade, such as transforming growth factor β (TGF-β) and fibronectin extra domain A (Fn-EDA) have been demonstrated to play a role in collagen deposition during keloid development, but how they are involved in the initiation and subsequent continuation of collagen deposition has remained unclear. To date, no one specific factor has been identified as the cause for keloid development, however, several pathologic etiologies have been described. Keloids can be a significant burden for the affected individual in terms of cosmetic harm, pruritus, pain and in severe cases, limited joint movement ( Fig. After surgical treatment, keloids tend to recur inevitably and the recurrence often exacerbates the condition. Keloids continue to grow over the years and they rarely regress spontaneously. Keloid tissue is characterized by an overabundant accumulation of extracellular matrix (ECM) components, especially collagen, in the dermis and subcutaneous tissue that extends beyond the confines of the original wound site. Keloids represent benign fibroproliferative tumors originating in response to trauma to the skin.
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